• Category Products

Key Applications

  • Deformulation
  • Co-polymer Compositional Drift
  • Extractables & Leachables
  • Minor Component Identification
  • Chemical Troubleshooting
  • Degradation/Failure Analysis

Micro-Deposition Improves Analysis

DiscovIR’s unique temperature controlled, vacuum deposition method ensures that results are accurate and reproducible. Eluted peaks are first deposited in a film on to a rotating IR transparent disc. Next, an infrared beam passes through each concentrated spot and the detector automatically collects spectral data.

Concentrates Analytes in Minimal Area

Cryogenic temperature control of the Sample Disc minimizes the area of the deposited analyte. This results in a thicker sample layer and therefore Higher Sensitivity of the absorbance spectrum.


  • Micro-Deposition on Cryogenically-Cooled IR-transparent disc
  • Unique, Proprietary LC interface
    removes solvent interference
  • Collects real-time IR spectrum
  • On-line analysis
  • No sample handling!


Revolutionary Desolvation Technology enables total flexibility with mobile phase solvents for GPC-FTIR. Solid phase transmission FTIR Spectra free from solvent interference are acquired continuously during the chromatography. The system is fully automated and compatible with autosamplers.

Complete solvent removal combined with controlled temperature cryogenic deposition minimizes band spreading and maintains the chromatographic resolution.

Enhanced Resolution
Infrared Detection System for HPLC and GPC

System Overview

Operating PrincipleDirect deposition of column eluent on moving ZnSe sample disc
IR SpectrometerBuilt-in FTIR
IR Detector0.1 mm MCT
Wavenumber Range4000–700 cm-1
Data CollectionReal-time, with post-run analysis available
Spectrum TypeTransmittance through disc and solid-phase sample
Disc Capacity12-24 hours of chromatography
Window Temperature-100°C to +50°C

Data Station

PlatformWindows™ 10 PRO
Spectroscopy PackageGrams32
Standard Features• Real-time and post-run data collect
• Chromatographic / spectral workup
• Band chromatograms for chemical classes
• Ratio chromatograms for profiling trends
Library SearchLibrary Search Software included
Spectra compatible with all solid phase FTIR Libraries

DiscovIR-LC Configuration

Sample DeliveryMulti-Step Desolvation Interface
Flow Rates Accepted0.25 to 1.5 mL/min
Compatible SolventsWater, ACN, Methanol, THF, Chloroform
Compatible AdditivesVolatile buffers (ammonium carbonates, acetates, formates), trifluoroacetic acid (TFA), triethylamine (TEA)
SensitivityTypically 1ug per component
ChromatographAny Liquid Chromatograph System (supplied by user)

Retains Entire Chromatographic Run

The entire chromatographic run is applied as a solid deposit on the Sample Disc, preserving the resolution of the separation, therefore, the entire run is available to be scanned again in order to investigate subtle features and improve signal-to-noise.
The speed of the rotating Sample Disc can be adjusted to match concentration of the deposited sample.


Reversed phase LC-IR spectra collected in real time with physical solvent removal.